Relationship between C reactive protein and pulse pressure is not mediated by atherosclerosis or aortic stiffness. Commentary
Identifieur interne : 00AB10 ( Main/Exploration ); précédent : 00AB09; suivant : 00AB11Relationship between C reactive protein and pulse pressure is not mediated by atherosclerosis or aortic stiffness. Commentary
Auteurs : Jacques Amar [France] ; Jean-Bernard Ruidavets [France] ; Claire Bal Dit Sollier [France] ; Vanina Bongard [France] ; Henri Boccalon [France] ; Bernard Chamontin [France] ; Ludovic Drouet [France] ; Jean Ferrieres [France] ; Alberto Avolio [Australie]Source :
- Journal of hypertension [ 0263-6352 ] ; 2004.
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- Pascal (Inist)
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Abstract
Background Pulse pressure (PP), C reactive protein (CRP) and soluble intercellular adhesion molecule-1 (sICAM-1) levels have been associated with cardiovascular prognosis. Interestingly, previous reports have shown that PP was associated both with CRP and sICAM-1. The mechanisms underlying these associations remain unknown. On the one hand, it has been shown that PP influences, via endothelial function, the expression of various molecules, which in turn may generate inflammation. On the other hand, inflammation-induced changes in the arterial wall, modifying the PP, may be the confounding factor of these relationships. The aim of the present study was to investigate the role played by the arterial structure and the aortic stiffness on these relationships. Methods In a cross-sectional population sample of 891 healthy subjects, carotid-femoral pulse wave velocity and blood pressure were measured in the supine position. The common carotid intima-media thickness and the presence of plaques were assessed by ultrasonography. CRP and sICAM-1 levels were measured by an immunonephelemetric method and an immunoenzymatic method, respectively. Results A positive relationship was found between PP and CRP (P< 0.001). This relationship remained after adjustment for classical cardiovascular risk factors, and successively for mean blood pressure, intima-media thickness, presence of plaques and pulse wave velocity (P < 0.05). No significant association was observed between PP and sICAM-1. Conclusions The results of this study demonstrate that changes in arterial structure and in arterial stiffness are not confounding factors in the relationship between PP and CRP.
Affiliations:
- Australie, France
- Midi-Pyrénées, Nouvelle-Galles du Sud, Occitanie (région administrative)
- Sydney, Toulouse
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Commentary</title><author><name sortKey="Amar, Jacques" sort="Amar, Jacques" uniqKey="Amar J" first="Jacques" last="Amar">Jacques Amar</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Internal Medicine and Arterial Hypertension, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U558</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Ruidavets, Jean Bernard" sort="Ruidavets, Jean Bernard" uniqKey="Ruidavets J" first="Jean-Bernard" last="Ruidavets">Jean-Bernard Ruidavets</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U558</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sollier, Claire Bal Dit" sort="Sollier, Claire Bal Dit" uniqKey="Sollier C" first="Claire Bal Dit" last="Sollier">Claire Bal Dit Sollier</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Laboratory of Haematology, Lariboisière Hospital, Paris</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Bongard, Vanina" sort="Bongard, Vanina" uniqKey="Bongard V" first="Vanina" last="Bongard">Vanina Bongard</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U558</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Boccalon, Henri" sort="Boccalon, Henri" uniqKey="Boccalon H" first="Henri" last="Boccalon">Henri Boccalon</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Vascular Medicine, CHU Rangueil</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Chamontin, Bernard" sort="Chamontin, Bernard" uniqKey="Chamontin B" first="Bernard" last="Chamontin">Bernard Chamontin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Internal Medicine and Arterial Hypertension, CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Drouet, Ludovic" sort="Drouet, Ludovic" uniqKey="Drouet L" first="Ludovic" last="Drouet">Ludovic Drouet</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Laboratory of Haematology, Lariboisière Hospital, Paris</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U558</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Avolio, Alberto" sort="Avolio, Alberto" uniqKey="Avolio A" first="Alberto" last="Avolio">Alberto Avolio</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Graduate School of Biomedical Engineering, University of New South</s1><s2>Sydney</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of hypertension</title><title level="j" type="abbreviated">J. hypertens.</title><idno type="ISSN">0263-6352</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of hypertension</title><title level="j" type="abbreviated">J. hypertens.</title><idno type="ISSN">0263-6352</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aorta</term><term>Atherosclerosis</term><term>C reactive protein</term><term>Cardiovascular disease</term><term>Epidemiology</term><term>Hypertension</term><term>Intercellular adhesion molecule 1</term><term>Stiffness</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Athérosclérose</term><term>Protéine C réactive</term><term>Aorte</term><term>Appareil circulatoire pathologie</term><term>Rigidité</term><term>Protéine ICAM1</term><term>Epidémiologie</term><term>Hypertension artérielle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Pulse pressure (PP), C reactive protein (CRP) and soluble intercellular adhesion molecule-1 (sICAM-1) levels have been associated with cardiovascular prognosis. Interestingly, previous reports have shown that PP was associated both with CRP and sICAM-1. The mechanisms underlying these associations remain unknown. On the one hand, it has been shown that PP influences, via endothelial function, the expression of various molecules, which in turn may generate inflammation. On the other hand, inflammation-induced changes in the arterial wall, modifying the PP, may be the confounding factor of these relationships. The aim of the present study was to investigate the role played by the arterial structure and the aortic stiffness on these relationships. Methods In a cross-sectional population sample of 891 healthy subjects, carotid-femoral pulse wave velocity and blood pressure were measured in the supine position. The common carotid intima-media thickness and the presence of plaques were assessed by ultrasonography. CRP and sICAM-1 levels were measured by an immunonephelemetric method and an immunoenzymatic method, respectively. Results A positive relationship was found between PP and CRP (P< 0.001). This relationship remained after adjustment for classical cardiovascular risk factors, and successively for mean blood pressure, intima-media thickness, presence of plaques and pulse wave velocity (P < 0.05). No significant association was observed between PP and sICAM-1. Conclusions The results of this study demonstrate that changes in arterial structure and in arterial stiffness are not confounding factors in the relationship between PP and CRP.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Midi-Pyrénées</li><li>Nouvelle-Galles du Sud</li><li>Occitanie (région administrative)</li></region><settlement><li>Sydney</li><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Amar, Jacques" sort="Amar, Jacques" uniqKey="Amar J" first="Jacques" last="Amar">Jacques Amar</name></region><name sortKey="Amar, Jacques" sort="Amar, Jacques" uniqKey="Amar J" first="Jacques" last="Amar">Jacques Amar</name><name sortKey="Boccalon, Henri" sort="Boccalon, Henri" uniqKey="Boccalon H" first="Henri" last="Boccalon">Henri Boccalon</name><name sortKey="Bongard, Vanina" sort="Bongard, Vanina" uniqKey="Bongard V" first="Vanina" last="Bongard">Vanina Bongard</name><name sortKey="Chamontin, Bernard" sort="Chamontin, Bernard" uniqKey="Chamontin B" first="Bernard" last="Chamontin">Bernard Chamontin</name><name sortKey="Drouet, Ludovic" sort="Drouet, Ludovic" uniqKey="Drouet L" first="Ludovic" last="Drouet">Ludovic Drouet</name><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><name sortKey="Ruidavets, Jean Bernard" sort="Ruidavets, Jean Bernard" uniqKey="Ruidavets J" first="Jean-Bernard" last="Ruidavets">Jean-Bernard Ruidavets</name><name sortKey="Sollier, Claire Bal Dit" sort="Sollier, Claire Bal Dit" uniqKey="Sollier C" first="Claire Bal Dit" last="Sollier">Claire Bal Dit Sollier</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Avolio, Alberto" sort="Avolio, Alberto" uniqKey="Avolio A" first="Alberto" last="Avolio">Alberto Avolio</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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